External Links

Cytel published an excellent instructional video on best practices when considering the use of synthetic controls to address accelerated treatment approvals for rare disease, considering adaptive clinical trial design, and researching the effectiveness of new treatments. Leveraging some of the published data on PDS platform, this is a great introduction to a handful of success stories. In this video, Kristian Thorlund, SVP Real World Analytics at Cytel, demonstrates a few key examples of applied use for accelerated approval (Blinatumomab 2014) and exploration of dynamic Bayesian borrowing or applying methods of different randomization methods.

Read more from the published article, Minimizing control group allocation in randomized trials using dynamic borrowing of external control data - An application to second line therapy for non-small cell lung cancer

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