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Type(s) of Cancer
Lung Cancer
Study Phase
Phase 3
Study Completion Date
March 2022
NCT00632853Uploaded 04-20-2024
Access via NCI by Request
PDS UID: nci-data-542
Phase III Comparison of Thoracic Radiotherapy Regimens in Patients With Limited Small Cell Lung Cancer Also Receiving Cisplatin and Etoposide
Provider Information
Provider Data DescriptionDataset NCT00632853-D1-Dataset.csv (patients) is one of 3 datasets associated with PubMed ID 36623230. This dataset contains data presented in the publication except for most of the adverse event data.
SponsorAlliance for Clinical Trials in Oncology
Data ProviderNational Cancer Institute
Clinical Trials.gov Information
Brief SummaryRadiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as etoposide, carboplatin and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known which radiation therapy regimen is more effective when given together with chemotherapy in treating patients with limited-stage small cell lung cancer. This randomized phase III trial is comparing different chest radiation therapy regimens to see how well they work in treating patients with limited-stage small cell lung cancer.
ConditionsLung Cancer
Intervention TypeRadiation: Standard Radiation Dose Therapy
Drug: cisplatin
Drug: etoposide
Radiation: High Radiation Dose Therapy
Drug: carboplatin
Drug(s)Drug: cisplatin
Drug: etoposide
Drug: carboplatin
Total Enrolled731
RandomizationRandomized
Blinding MethodNone (Open Label)
Arms InterventionArm A - Standard Radiotherapy + Chemotherapy - Active Comparator
Arm B - High Dose Radiotherapy + Chemotherapy - Experimental
Secondary IDCALGB-30610
PubMed (PMID)N/A
Collaborator(s)National Cancer Institute (NCI)
Region(s)United States
Israel
Korea, Republic of
Puerto Rico
Age Range18 Years and older (Adult, Older Adult)
Files: NCT00632853-D1
Data DictionaryNCT00632853-D1-Data-Dictionary_1.pdf
DATANCT00632853-D1-Dataset_1.csv
OTHERREADME.pdf
Files: NCT00632853-D2
Data DictionaryNCT00632853-D2-Data-Dictionary_1.pdf
DATANCT00632853-D2-Dataset.csv
OTHERREADME.pdf
Files: NCT00632853-D3
Data DictionaryNCT00632853-D3-Data-Dictionary_1.pdf
DATANCT00632853-D3-Dataset.csv
OTHERREADME.pdf
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