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Treatment of Childhood Nasopharyngeal Carcinoma With Neoadjuvant Chemotherapy and Concomitant Chemoradiotherapy: A Groupwide Phase III Study
Provider Data DescriptionNCT00274937-D1-Dataset (Main)
This dataset provides data required for reproducing all quantitative statements in the manuscript except for the toxicity table presented as Table A1 in the APPENDIX.
Blanks represent missing data or not applicable for analysis. All patients are eligible.
There is one row per patient.
SponsorChildren's Oncology Group
Data ProviderNational Cancer Institute
Clinical Trials.gov Information
Brief SummaryThis phase III trial is studying how well radiation therapy, amifostine, and chemotherapy work in treating young patients with newly diagnosed nasopharyngeal cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs, such as amifostine, may protect normal cells from the side effects of radiation therapy. Drugs used in chemotherapy, such as cisplatin and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with amifostine and chemotherapy may kill more tumor cells.
ConditionsStage I Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7 Stage I Nasopharyngeal Undifferentiated Carcinoma AJCC v7 Stage II Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7 Stage II Nasopharyngeal Undifferentiated Carcinoma AJCC v7 Stage III Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7 Stage III Nasopharyngeal Undifferentiated Carcinoma AJCC v7 Stage IV Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7 Stage IV Nasopharyngeal Undifferentiated Carcinoma AJCC v7